Difference Between Platelet-Rich Plasma (PRP) And Platelet-Rich Fibrin Matrix (PRFM)

By: | Updated: Aug-31, 2023
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The medical world constantly evolves, introducing new and improved treatments to address various ailments and enhance overall wellness. Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin Matrix (PRFM) are among these advancements. Both offer potential in regenerative medicine, yet they’re distinctly unique.  

This article delves into their differences, highlighting their applications and effects. It also provides a clearer understanding of PRP and PRFM and the role of products like Selphyl Ortho in the medical space. 

Difference Between Platelet-Rich Plasma (PRP) And Platelet-Rich Fibrin Matrix (PRFM)

1. Definition And Composition 

Understanding the fundamental components of PRP and PRFM provides insight into their therapeutic potential.

A. What’s Platelet-Rich Plasma (PRP)? 

Platelet-rich plasma, commonly referred to as PRP, originates from your blood. By concentrating the platelets, PRP offers a solution packed with cells that play a pivotal role in healing. 

When tissue damage or injury occurs, these platelets rush to the affected area, offering critical support for repair and growth. They release growth factors, proteins essential for healing. Moreover, because PRP comes from your body, the risk of allergic reactions or incompatibility is significantly reduced.

B. What About Platelet-Rich Fibrin Matrix (PRFM)?  

PRFM steps up the game. While it originates from your blood, it offers something extra, which is fibrin. It’s a protein with an essential role in the clotting process, forming a mesh that holds platelets in place. 

The presence of fibrin in PRFM acts as a scaffold, enhancing tissue regeneration and providing a structure where cells can proliferate. It creates a more controlled and prolonged release of the growth factors, optimizing the healing process. 

2. Extraction And Preparation Process 

Delving into how these therapeutic solutions are derived from blood clarifies their preparation methods.

A. Extracting PRP 

Creating PRP begins with drawing a blood sample, which is then subjected to centrifugation. Different blood components get separated during this spinning process based on their densities. The end product? A concentrated collection of platelets suspended in a small volume of plasma, ready to work their magic in various treatments.

B. Producing PRFM

For PRFM, the journey starts similarly—blood is drawn and spun. Following the centrifugation, an activator, often calcium chloride, is introduced. This chemical addition catalyzes the conversion of fibrinogen in the plasma to fibrin. The end product is a gel-like matrix enriched with platelets. 

3. Applications And Benefits 

Highlighting the therapeutic uses and advantages of PRP and PRFM showcases the broad range of applications and inherent benefits.

A. PRP Uses 

Over the years, the applications of PRP have expanded. It’s not just limited to healing injuries; the cosmetic world has embraced it for procedures to rejuvenate the skin. It can revitalize the skin by promoting collagen production and enhancing blood supply, giving it a youthful glow. In orthopedics, it aids in the speedy recovery of injuries, minimizing inflammation and pain.

B. PRFM Advantages 

PRFM, with its unique fibrin scaffold, promises even more. It ensures that platelets stay where they’re most needed, gradually releasing growth factors. This sustained release translates to prolonged therapeutic effects in areas like orthopedics. Products such as Selphyl Ortho harness the power of PRFM to optimize patient outcomes, enhancing the repair of tendons, ligaments, and other tissues. 

4. Limitations And Concerns 

Understanding both treatments’ potential drawbacks and challenges offers a balanced view of their efficacy and limitations.

A. PRP Shortcomings 

While PRP holds promise, it isn’t flawless. Outcomes can differ from one individual to another. Some might witness incredible results, while others see little to no change. Moreover, since it involves injections, there’s always the inherent risk of infection or tissue damage. It’s also worth noting that while allergic reactions are rare, they aren’t entirely impossible.

B. PRFM Considerations 

PRFM, due to its fibrin matrix, presents a thicker consistency. It can sometimes mean a bit more discomfort during injection. Also, just like PRP, there’s no guaranteed outcome. Each person’s body reacts differently, and while many experience benefits, some might not see the results they hoped for. 

5. Key Distinctions 

Drawing out the primary differences between PRP and PRFM helps discern the unique attributes and superiorities.

A. Duration Of Effect 

One of the most significant distinctions lies in their lasting impact. The fibrin matrix in PRFM allows a more regulated, sustained release of the beneficial growth factors. It potentially extends its therapeutic effects, offering longer-lasting benefits compared to PRP, which has a more immediate but potentially shorter-lived effect.

B. Cost And Accessibility

Another key difference between PRP and PRFM lies in their cost and accessibility. Generally, PRP is more widely available and tends to be more affordable. On the other hand, the added steps in the production of PRFM, including the introduction of an activator to produce the fibrin matrix, can result in a higher cost for the treatment. 

Additionally, PRFM treatments may not be as readily available in all healthcare settings, potentially requiring specialized facilities or expertise. This distinction is crucial for individuals weighing their options based on budget and location.


In the realm of regenerative medicine, both PRP and PRFM have cemented their places. While they share similarities, understanding their differences ensures you can decide which treatment might be best for you. Stay informed, and always consult a medical professional before making health-related decisions.

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